## Drug Name Atorvastatin / Lipitor ## Drug Class Statin (HMG-CoA reductase inhibitor) ## Indications Atorvastatin is primarily used for the treatment of hyperlipidemia and mixed dyslipidemia. It is effective in lowering elevated total cholesterol, LDL cholesterol, and triglycerides. Additionally, atorvastatin is prescribed for the prevention of cardiovascular disease, including reducing the risk of myocardial infarction, stroke, and angina in individuals with multiple risk factors for coronary heart disease. ## Common Side Effects - Headache - Nasopharyngitis - Diarrhea - Arthralgia - Insomnia ## Serious Side Effects - Rhabdomyolysis with acute renal failure secondary to myoglobinuria - Hepatotoxicity - Pancreatitis - Severe myopathy - Hemorrhagic stroke ## Warnings / Contraindications Atorvastatin is contraindicated in patients with active liver disease or unexplained persistent elevations of hepatic transaminase levels. It should not be used during pregnancy (Category X) or lactation. Patients with a history of hypersensitivity to atorvastatin or any component of the product should avoid use. Caution is advised when used in patients with a history of liver disease or heavy alcohol use. ## Dosage Forms - Oral tablet: 10 mg, 20 mg, 40 mg, and 80 mg ## Pharmacy Technician Notes - Patients should be advised to take atorvastatin at the same time each day, with or without food. - Grapefruit and grapefruit juice can increase the risk of side effects and should be avoided. - Monitor for muscle pain, tenderness, or weakness, particularly if accompanied by fever or malaise. - Liver function tests should be performed before starting therapy and periodically thereafter. - Be aware of potential drug interactions with other medications such as cyclosporine, certain antibiotics, and antifungal medications. ## Summary Atorvastatin is a cornerstone medication in the management of hyperlipidemia and the prevention of cardiovascular events. Its ability to lower LDL cholesterol and triglycerides makes it a vital part of cardiovascular risk reduction strategies. Pharmacy technicians should ensure patients understand the importance of adherence to therapy, monitoring for side effects, and avoiding grapefruit products. Proper counseling on these points can enhance patient outcomes and reduce the risk of serious side effects.