## Primary Drug Warfarin ## Interacting Drug Ibuprofen ## Type of Interaction Pharmacodynamic ## Mechanism NSAIDs like ibuprofen can interfere with platelet function and increase the risk of bleeding when taken concomitantly with warfarin, an anticoagulant. ## Clinical Significance The interaction between warfarin and NSAIDs can lead to an increased risk of bleeding due to additive effects on blood clotting. This can result in serious consequences such as gastrointestinal bleeding or hemorrhagic stroke. ## Management / Monitoring Patients should be monitored for signs of bleeding, such as easy bruising, black or tarry stools, or blood in the urine. Dosage adjustment of warfarin may be necessary, and alternative pain management options should be considered. ## Pharmacy Technician Notes - Advise patients to inform healthcare providers about all medications they are taking, including over-the-counter NSAIDs like ibuprofen. - Emphasize the importance of regular monitoring for signs of bleeding and the need for follow-up with healthcare providers. - Provide examples of NSAIDs to avoid or use with caution when taking warfarin, such as aspirin, naproxen, or celecoxib.