## Primary Drug Warfarin ## Interacting Drug Ibuprofen ## Type of Interaction Pharmacodynamic ## Mechanism Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), can inhibit platelet function and interfere with the anticoagulant effects of warfarin. ## Clinical Significance This interaction can lead to an increased risk of bleeding due to reduced platelet aggregation and anticoagulant effects of warfarin, potentially resulting in serious bleeding complications. ## Management / Monitoring Patients should be monitored closely for signs of bleeding, such as easy bruising, prolonged bleeding from cuts, or blood in urine or stool. Dosage adjustments of warfarin may be necessary if ibuprofen is used concurrently. Alternative pain management options should be considered. ## Pharmacy Technician Notes - Advise patients to inform healthcare providers if they are taking both warfarin and ibuprofen.- Emphasize the importance of monitoring for signs of bleeding and promptly reporting any unusual bleeding events.- Recommend using acetaminophen as a safer alternative for pain relief in patients on warfarin therapy.- Encourage patients to consult a pharmacist or healthcare provider before starting any new medications to avoid potential drug interactions.