## Primary Drug Warfarin ## Interacting Drug NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) ## Type of Interaction Pharmacodynamic ## Mechanism NSAIDs can interfere with the anticoagulant effects of warfarin by displacing it from protein-binding sites, leading to increased bleeding risk. ## Clinical Significance The interaction between warfarin and NSAIDs can result in reduced efficacy of warfarin, potentially increasing the risk of blood clots and thromboembolic events. It can also lead to an elevated INR (International Normalized Ratio) and an increased risk of bleeding. ## Management / Monitoring Patients taking warfarin and NSAIDs should be closely monitored for signs of bleeding or changes in INR levels. Dosage adjustments of warfarin may be necessary. Alternative pain management options should be considered to minimize the risk of adverse effects. ## Pharmacy Technician Notes - Counsel patients on the potential interaction between warfarin and NSAIDs, advising them to avoid over-the-counter NSAIDs without consulting a healthcare provider. - Encourage patients to inform all healthcare providers about the use of warfarin and other medications, including NSAIDs, to prevent adverse drug interactions. - Emphasize the importance of regular monitoring of INR levels and reporting any unusual bleeding or bruising to healthcare providers promptly.