## Primary Drug Warfarin ## Interacting Drug Aspirin ## Type of Interaction Pharmacodynamic ## Mechanism Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), may increase the risk of bleeding when used concomitantly with warfarin by affecting platelet function and impairing the clotting cascade. ## Clinical Significance The interaction between warfarin and aspirin can lead to an increased risk of bleeding, potentially causing serious health complications. ## Management / Monitoring Patients should be monitored for signs of bleeding, including easy bruising, blood in urine or stool, or prolonged bleeding from minor cuts. Dosage adjustments of warfarin may be necessary, and alternative pain management options should be considered. ## Pharmacy Technician Notes - Advise patients to inform healthcare providers about all medications, including over-the-counter drugs like aspirin, before starting warfarin therapy. - Emphasize the importance of regular monitoring and reporting any signs of bleeding promptly. - Suggest the use of acetaminophen instead of aspirin for pain relief when taking warfarin to minimize the risk of bleeding events.