## Primary Drug Warfarin ## Interacting Drug Aspirin ## Type of Interaction Pharmacodynamic ## Mechanism Aspirin can displace warfarin from protein binding sites, leading to an increase in free warfarin levels in the blood. ## Clinical Significance This interaction can potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. ## Management / Monitoring Monitor closely for signs of bleeding, adjust warfarin dosage if necessary, and consider using alternative pain relief options. ## Pharmacy Technician Notes - Counsel patients on the signs of bleeding, such as easy bruising or bleeding gums. - Advise patients to inform healthcare providers about all medications, including over-the-counter drugs like aspirin. - Suggest the use of acetaminophen instead of aspirin for pain relief in patients taking warfarin.