## Primary Drug Warfarin ## Interacting Drug Aspirin ## Type of Interaction Pharmacodynamic ## Mechanism Aspirin can displace warfarin from protein-binding sites, leading to an increased concentration of free warfarin in the blood. ## Clinical Significance This interaction can potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. ## Management / Monitoring Monitor the patient's INR (International Normalized Ratio) closely when starting or stopping aspirin therapy. Adjust warfarin dosage as needed. ## Pharmacy Technician Notes - Advise patients to inform all healthcare providers about the use of warfarin and aspirin. - Highlight the importance of regular INR monitoring to prevent bleeding complications. - Recommend using acetaminophen as an alternative pain reliever if needed to avoid interactions with warfarin.